$148.20Catalog Number: PYT050-10ugSize: 10ug

IL 23 Human

Interleukin-23 Human Recombinant

IL-23 Human Recombinant produced in HEK 293 cells is a disulfide-linked heterodimer, containing one polypeptide chain p19 subunit containing 169 amino acids and one polypeptide chain IL-12B p40 subunit containing 306 amino acids, with the total molecular weight of 53kDa (not including glycosylation).
The IL-23 is purified by proprietary chromatographic techniques.

Accession

Q9NPF7

Amino acid sequence

p19 Subunit: AVPGGSSPAW TQCQQLSQKL CTLAWSAHPL VGHMDLREEG DEETTNDVPH IQCGDGCDPQ GLRDNSQFCL QRIHQGLIFY EKLLGSDIFT GEPSLLPDSP VGQLHASLLG LSQLLQPEGH HWETQQIPSL SPSQPWQRLL LRFKILRSLQ AFVAVAARVF AHGAATLSP
p40 Subunit: IWELKKDVYV VELDWYPDAP GEMVVLTCDT PEEDGITWTL DQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGEVLSHSLL LLHKKEDGIW STDILKDQKE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDPQGVTCGA ATLSAERVRG DNKEYEYSVE CQEDSACPAA EESLPIEVMV DAVHKLKYEN YTSSFFIRDI IKPDPPKNLQ LKPLKNSRQV EVSWEYPDTW STPHSYFSLT FCVQVQGKSK REKKDRVFTD KTSATVICRK NASISVRAQD RYYSSSWSEW ASVPCS

Biological Activity

The activity, as determined by the dose dependent production of IL-17A from mouse splenocytes and is typically less than 5ng/ml.

Formulation

IL-23 was lyophilized from 10mM Na2PO4, pH 7.5.

Physical Appearance

IL-23 if supplied as a sterile filtered White lyophilized (freeze-dried) powder.

Purity

Greater than 95.0% as determined by analysis by SDS-PAGE.

Solubility

It is recommended to reconstitute the lyophilized Interleukin-23 in sterile 18MΩ-cm H2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.

Source

HEK 293 cells

Stability

Lyophilized Interleukin-23 although stable at room temperature for 3 weeks, should be stored desiccated below -18oC. Upon reconstitution IL-23 should be stored at 4oC between 2-7 days and for future use below -18oC.
Please avoid multiple freeze-thaw cycles.

Synonyms

interleukin 23 alpha subunit p19, interleukin-12 subunit beta p40, SGRF, IL23P19, IL-23-A, interleukin-six, G-CSF related factor, JKA3 induced upon T-cell activation, interleukin 12B (natural killer cell stimulatory factor 2 cytotoxic lymphocyte maturation factor 2 p40), NK cell stimulatory factor chain 2, Cytotoxic lymphocyte maturation factor 40 kDa subunit, CLMF2, CLMF p40.

Quantity

$148.20

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