$90.00Catalog Number: PYT069-10ugSize: 10ug

TNFRSF10B Human

TNF Ligand Receptor Superfamily Member 10B Human Recombinant

TNFRSF10B Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 133 amino acids and having a molecular mass of 14.9kDa.
The TNFRSF10B is purified by proprietary chromatographic techniques.

Accession

O14763

Amino acid sequence

MESALITQQD LAPQQRVAPQ QKRSSPSEGL CPPGHHISED GRDCISCKYG QDYSTHWNDL
LFCLRCTRCD SGEVELSPCT TTRNTVCQCE EGTFREEDSP EMCRKCRTGC PRGMVKVGDC
TPWSDIECVH KES

Biological Activity

The TNFRSF10B reduced the production of LPS-induced TNF by its ability to neutralize endogenous TRAIL in fresh human PBMC. In this assay, endogenous TRAIL is induced during a 24 hour exposure to LPS (10ng/mL) but in the presence of TNFRSF10B, TRAIL-induced TNF is suppressed.

Formulation

Lyophilized from a 0.2um filtered concentrated solution in PBS, pH7.4

Physical Appearance

Sterile Filtered White lyophilized (freeze-dried) powder

Purity

Greater than 95.0% as determined by

(a) Analysis by HPLC.
(b) Analysis by SDS-PAGE.

Solubility

It is recommended to reconstitute the lyophilized TNFRSF10B in sterile 18MΩ-cm H2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.

Source

Escherichia Coli

Stability

Lyophilized TNFRSF10B although stable at room temperature for 3 weeks, should be stored desiccated below -18oC. Upon reconstitution TNFRSF10B should be stored at 4oC between 2-7 days and for future use below -18oC. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.

Synonyms

Tumor necrosis factor receptor superfamily member 10B, Death receptor 5, TNF-related apoptosis-inducing ligand receptor 2, TRAIL receptor 2, TRAIL-R2, CD262, TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9, TRICKB, TRICK2A, TRICK2B, KILLER/DR5

Quantity

$90.00

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