Recombinant 31-O-demethyl-FK506 methyltransferase FkbM (fkbM)

Recombinant 31-O-demethyl-FK506 methyltransferase FkbM (fkbM) can be expressed and purified from different hosts. E. coli and yeast offers the best yields and shorter turnaround times. Expression in insect cells with baculovirus or mammalian cells can provide many of the posttranslational modifications necessary for correct protein folding or retain the proteins activity.