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$678.00Catalog Number: BXJ1105-aaSize: 20 ug

pMEVHA-JNK1-AA

Human JNK1 (MAPK8) Xpress Clones

Mitogen-activated protein kinases (MAPKs) cascade relays extracellular signals from cell membrane to the nucleus to induce intracellular responses and to regulate many aspects of cell physiology. These cascades, including JNK, ERK and p38 pathways, consist of distinct members of regulatory enzymes that serially activate one another in response to growth factors, cytokines and other mitogenic stimuli, leading to (in)activation of transcription factors. Activation by external stimuli like UV of the Jun N-terminal Kinase (JNK) pathway increases the expression of a set of autoimmune and inflammatory genes, including IL-2 and gamma interferon. Multiple subtypes of the enzyme induce cell- and stimulus- specific responses. The mutation K55M renders the enzyme catalytically inactive.

Includes and available separately

BXJ1105-4:20 ug each
BXJ1105-wt:20 ug
BXJ1105-km:20 ug
BXJ1105-ee:20 ug
BXJ1105-aa:20 ug

Custom size is also available upon request.

Materials Provided:20 ug transfection ready plasmids in 40ul TE buffer.
Antibiotic Selections:Kan/Neo for kanamycin selectin in bacteria and G418 selection in mammalian cells
Cloning vector:pMEV-2HA
5' cloning site:Bam HI
3' cloning site:Kpn I
GenBank#:NM_002750
Mutations:K55M; T183E, Y185E; T183A, Y185A
Quantity

$678.00

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