Human IRAK4 Xpress Clones
Interleukin-1 receptor-associated kinases (IRAK), identified as a serine/threonine kinases coprecipitated with IL-1 receptor (IL-1R) in an IL-1 inducible manner, share significant homology to pelle. The mammalian family of IRAK consists of two active kinases, IRAK-1 and IRAK-4; and two inactive kinases, IRAK-2 and IRAK-M. They are implicated in the TLR/IL-1R pathway to both IKK and MAPKs activation, leading to the activation of transcription factors like NF-kB and AP-1.
Human IRAK-4 gene (AF445802) encodes a protein of 52kDa, linked to Ptk9. Northern blots show its expression predominantly in kidney and liver samples, although RT-PCR show low level expression in multiple tissues. Like other IRAKs, IRAK-4 is a multidomain protein, consisting of N-terminal death domain (DD) and a central kinase domain (KD) but lacks the long uniques C-terminal domain. Mutation in the ATP binding pocket, KK213AA renders the enzyme catalytically inactive. In contrast to kinase deficient IRAK-1-KD, which is still able to activate NF-kB and does not inhibit IL-1-dependent signaling, kinase deficient IRAK-4-KK213AA strongly diminished IL-1-induced NF-kB activation suggesting a biological function of the kinase domain in the signal transduction pathways.
Gene Name: Homo sapiens interleukin-1 receptor-associated kinase 4.
Includes and available separately
BXP1055-2: | 20 ug each |
---|
BXP1055-wt: | 20 ug |
---|
BXP1055-ka: | 20 ug |
---|
| |
---|
| |
---|
Custom size is also available upon request.