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$678.00Catalog Number: BXW1000-dnSize: 20 ug

pMEV2HA-IkBa-DN

Human IκB alpha Xpress Clones

I kappa B proteins (IκBs) bind to and inhibit the NF-κB complex by trapping it in the cytoplasm (OMIM #164008). IkBs could be phosphorylated by IKKs and subsequently polyubiquitinated for degradation to allow translocation of NF-κB into the nucleus. Serines 32 and 36 in the N terminal regulatory domain of IkBa are the conserved phosphorylation sites. Substitution with alanines (S32A and S36A) of the phosphoacceptor sites would block the phosphorylation and degradation of IkBa by IKKs.

Gene Name: Homo sapiens I kappa B alpha (IκBα).

Includes and available separately

BXW1000-2:20 ug each
BXW1000-wt:20 ug
BXW1000-dn:20 ug

Custom size is also available upon request.

Materials Provided:20 ug transfection ready plasmids in 40ul TE buffer.
Antibiotic Selections:Kan/Neo for kanamycin selectin in bacteria and G418 selection in mammalian cells
Cloning vector:pMEV-2HA
5' cloning site:Bam HI
3' cloning site:Xba I
GenBank#:NM_020529
Mutations:DN: S32A and S36 A
Quantity

$678.00

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