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$1,627.20Catalog Number: BXP1070-4Size: 20 ug each

Human P38, Set of 4

Human P38 Xpress Clones

Mitogen-activated protein kinases (MAPKs) cascade relays extracellular signals from cell membrane to the nucleus to induce intracellular responses and to regulate many aspects of cell physiology. These cascades, including JNK, ERK and p38 pathways, consist of distinct members of regulatory enzymes that serially activate one another in response to growth factors, cytokines and other mitogenic stimuli, leading to (in)activation of transcription factors. Proinflammatory cytokine and microbial products activate p38 (SAPK2) gene regulating pathway and cause the expression of multiple cytokine genes including IL-1, IL-6 and TNF alpha. The mutation p38 K53M renders the enzyme catalytically inactivate.

Gene Name: Homo sapiens mitogen-activated protein kinase 14 (MAPK14), transcript variant 1.

Includes and available separately

BXP1070-4:20 ug each
BXP1070-wt:20 ug
BXP1070-km:20 ug
BXP1070-ee:20 ug
BXP1070-aa:20 ug

Custom size is also available upon request.

Materials Provided:20 ug transfection ready plasmids in 40ul TE buffer.
Antibiotic Selections:Kan/Neo for kanamycin selectin in bacteria and G418 selection in mammalian cells
Cloning vector:pMEV-2HA
5' cloning site:Bam HI
3' cloning site:Kpn I
GenBank#:NM_001315
Mutations:K53M; T183E, Y185E; T183A, Y185E
Quantity

$1,627.20

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