$301.50Catalog Number: MA068343A0m-1Size: 100 ug

Human NGAL Mab

mouse anti- Human Neutrophil gelatinase-associated lipocalin/NGAL monoclonal Antibody

Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.

For more information about different types of antibodies and their properties, please visit Wikipedia Antibody. For information on functions, splicing variants and sequences of the target protein, please visit UniProt.org. For expression levels and tissue distribution of the target protein please visit bioGPS.org.

Download the user's guide with the link at bottom of page.pdf manual

Antobody Specifications


AmountIsotypeSupplied In
100ugIgG2bSee below

ImmunogenRecombinant Human Neutrophil gelatinase-associated lipocalin/NGAL protein
Specificityspecific for native and denatured forms
ApplicationsELISA(Recommended pairs for the detection of Double-antibody sandwich ELISA), WB, and other applications
Supplied inPreservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purity>95% by Caprylic Acid Ammonium Sulfate Precipitation purified
StorageStore at +4oC short term (1-2 weeks). Aliquot and store at -20oC or -80oC. Avoid repeated freeze / thaw cycles.
Quantity

$301.50

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