$301.50Catalog Number: MA061901A0m-1Size: 100 ug

Human Cystatin C Mab

Mouse anti- Human Cystatin C monoclonal Antibody

Defects in CST3 are the cause of amyloidosis type 6 (AMYL6) [MIM:105150]; also known as hereditary cerebral hemorrhage with amyloidosis (HCHWA), cerebral amyloid angiopathy (CAA) or cerebroarterial amyloidosis Icelandic type. AMYL6 is a hereditary generalized amyloidosis due to cystatin C amyloid deposition. Cystatin C amyloid accumulates in the walls of arteries, arterioles, and sometimes capillaries and veins of the brain, and in various organs including lymphoid tissue, spleen, salivary glands, and seminal vesicles. Amyloid deposition in the cerebral vessels results in cerebral amyloid angiopathy, cerebral hemorrhage and premature stroke. Cystatin C levels in the cerebrospinal fluid are abnormally low.Genetic variations in CST3 are associated with age-related macular degeneration type 11 (ARMD11) [MIM:611953]. ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.

For more information about different types of antibodies and their properties, please visit Wikipedia Antibody. For information on functions, splicing variants and sequences of the target protein, please visit UniProt.org. For expression levels and tissue distribution of the target protein please visit bioGPS.org.

Download the user's guide with the link at bottom of page.pdf manual

Antobody Specifications


AmountIsotypeSupplied In
100ugIgG2bSee below

ImmunogenRecombinant Human Cystatin C protein
Specificityspecific for native and denatured forms
ApplicationsELISA, WB, and other applications
Supplied inPreservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purity>95% by Caprylic Acid Ammonium Sulfate Precipitation purified
StorageStore at +4oC short term (1-2 weeks). Aliquot and store at -20oC or -80oC. Avoid repeated freeze / thaw cycles
Quantity

$301.50

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