Endostatin Human Recombinant
Endostatin Human Recombinant produced in Pichia Pastoris is a single, glycosylated, polypeptide having a total molecular mass of 20,000 Dalton C-terminal fragment of collagen XVIII that has been shown to act as a potent inhibitor of angiogenesis and tumor growth in vitro and in vivo. Induces tyrosine phosphorylation of Shc (SH2 domain adapter protein) leading to specific inhibition in endothelial cell prolifiration.
The Endostatin is purified by proprietary chromatographic techniques.
Accession
Amino acid sequence
In total agreement with the expected amino acid composition of native human Endostatin.
Biological Activity
The activity calculated by ECE migration inhibition was found to be 50,000IU/mg.
Formulation
The recombinant Human Endostatin is formulated with PBS.
Physical Appearance
Sterile filtered liquid formulation.
Purity
Greater than 98.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Source
Stability
Endostatin although stable at 4oC for 30 days, should be stored desiccated below -20oC for periods greater than 30 days.
Please avoid Freeze/Thaw cycles.
